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William Harvey demonstrating his theory of circulation of the blood before Charles I. Oil painting by Ernest Board. William Harvey (April 11, 1578 - June 3, 1657) was an English physician and the first person to accurately determine how the heart circulated blood throughout human and animal bodies. He was also the first to posit the theory that humans and other mammals reproduced when an egg was fertilized by sperm. His work "De Motu Cordis" [On the motion of the heart and blood in animals], published in 1628, remains a milestone in medicine.