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John K. Smith (died 1845) was the founder of SmithKline as in GlaxoSmithKline, the leading pharmaceutical business. Trained as a druggist, John K.Smith joined with his brother-in-law, John Gilbert, in 1830 to open a dispensing chemist at 296 North Second Street in Philadelphia. Together they sold drugs, paints, varnish, chemicals and window glass. When he decided to retire he handed the business on to his son, George K. Smith, who expanded it into a large international business.