Isabella Romola de Medici (31 August 1542 to 16 July 1576) was the third of eleven children and the second eldest daughter of Cosimo I de Medici, the first Grand Duke of Tuscany, and his first wife Eleonora Alvarez de Toledo y Osorio, painting by Alessandro Allori, digitally restored reproduction from an original of the time.
Isabella Romola de Medici (31 August 1542 to 16 July 1576) was the third of eleven children and the second eldest daughter of Cosimo I de Medici, the first Grand Duke of Tuscany, and his first wife Eleonora Alvarez de Toledo y Osorio, painting by Alessandro Allori, digitally restored reproduction from an original of the time